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Ovarian Cancer

Ovarian cancer has an important place among female genital cancers.

Op.Dr. Hüseyin Kılıç is one of the physicians in Istanbul who performs advanced ovarian cancer surgeries. Dr. Kılıç treats and monitors hundreds of ovarian cancer surgeries.

Although it is not known exactly how ovarian cancer develops, there are different theories. It is followed with the 2nd frequency among female genital cancers and the rate of ovarian cancer in a woman's lifetime is 1.4%.

Ovarian cancer can occur in different age groups, especially depending on its type. In particular, tumors that develop from the surface of the ovary are more common during menopause. Apart from that, the group we call germ cell ovarian tumor is mostly seen under 20 years of age, and the group we call sex cord stromal tumor is seen between 40-50 years old.

Signs of ovarian cancer

Ovarian cancer is a disease that progresses insidiously because it is a late finding disease. It may not cause any symptoms in the early stages

  • Abdominal swelling
  • Relevant audience
  • Abdominal pain
  • Indigestion
  • Anorexia
  • Nausea
  • Constipation
  • Low back pain
  • Shortness of defecation etc.

Genetic basis of ovarian cancer

There is a risk of familial breast-ovarian cancer syndrome especially in mutation carriers in cancer suppressor genes, which we call BRCA1 and BRCA2. This group of tumors can occur at younger ages. For this reason, people with such a history in themselves and in their families should be genetically investigated. Hereditary nonpolyposis colorectal cancer syndrome, also known as Lynch2 syndrome, has a 10% risk of ovarian cancer and 30-40% uterine (endometrial) cancer.

The removal of the uterus and ovaries should be prioritized in this group of patients, especially in patients over 40 years of age who do not want a child.

Tumor markers in ovarian cancer

The most studied tumor marker in ovarian cancer screening is CA-125. CA-125 levels are increased in 85% of epithelial ovarian cancers, but are elevated in 50% of patients with stage 1. It is significant that the level of CA-125 is high (>35) especially in cases with postmenopausal abdominal mass. On the other hand, CA-125 levels may increase in various benign conditions (endometriosis, pelvic infection, adenomyosis, liver diseases, peritonitis, pancreatitis, etc.) other than ovarian cancer. Tumor markers such as AFP, HCG and LDH are also used in younger ovarian tumors.

Scan and prevent

Unfortunately, there is no proven effective screening method for individuals with normal or family history. It is recommended to use drugs called oral contraceptives (OCS), especially in young individuals with a family history and who do not have children.

Treatment of Ovarian Cancer - İstanbul

The main treatment for ovarian cancer is surgery followed by chemotherapy. In very early homes, chemotherapy may not be given sometimes. Ovarian cancer surgery is a situation that requires experience. In fact, the life expectancy of patients may be shortened in surgeries performed by those who have no experience in scientific studies. The most important factor in the treatment of ovarian cancers is to perform an operation that does not leave any tumors behind. The treatment of these tumors must be done by experienced gynecological oncology specialists.

Gynecological cancer surgery specialist Op.Dr. for the diagnosis, treatment and follow-up of ovarian cancer. Hüseyin Kılıç provides service in Istanbul.

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